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Below is a description of the PromoterCAD Application.
Name: RIKEN GenoCon
Affiliation: RIKEN The Institute of Physical and Chemical Research
Date: 2013-01-17
PromoterCAD uses plant gene sequence and expression data to create synthetic promoters for tissue and time specific expression. The experimental test of such synthetic promoters will be to measure firefly Luciferase in Arabidopsis plant body. The program provides a graphical user interface (GUI), so anyone can design promoters using options in a series of select menus and push buttons. The program is written in JavaScript, on an open platform that allows for easy user customization.
The program provides several plugin tools for promoter designs MotifExpress, and MotifCircadian function, as well as LocusSelect function for graph visualization of expression data. MotifExpress picks up the sequence motifs from the gene with maximum/minimum expression in a specific developmental condition or time of day. MotifCircadian picks up the motifs with maximum circadian amplitude. Output includes visualization such as HighCharts graph visualization of expression data under experimental conditions (AtGenExpress) and time evolution of expression under circadian conditions (DIURNAL). Programmers can easily fork and add to these functions following the PromoterCAD manuals and help pages:
For detail of GenoCon2 Promoter Design Challenge, please see the Promoter Design Challenge page. If you are ready to submit a design to GenoCon2, please check the manual for Promoter Design Submission. If you want to learn more about the PromoterCAD software and data, check out the PromoterCAD homepage.